Here are the best practices to tune a BSO database:
1. ACR (Average clustering Rate) should be as close to 1 as possible. If it is higher you can launch a dense restructure to de-fragment the database.
2. Block Size should be between 8 and 100KB (can be more on 64 bit systems).
3. Data cache should be 12.5% of the pag files.
4. Index cache should be the same size as the ind files.
5. You should have 1 Database per Application.